Effects of rapid urbanisation on the urban thermal environment between 1990 and 2011 in Dhaka Megacity, Bangladesh

This study investigates the influence of land-use/land-cover (LULC) change on land surface temperature (LST) in Dhaka Megacity, Bangladesh during a period of rapid urbanisation. LST was derived from Landsat 5 TM scenes captured in 1990, 2000 and 2011 and compared to contemporaneous LULC maps. We compared index-based and linear spectral mixture analysis (LSMA) techniques for modelling LST. LSMA derived biophysical parameters corresponded more strongly to LST than those produced using index-based parameters. Results indicated that vegetation and water surfaces had relatively stable LST but it increased by around 2 °C when these surfaces were converted to built-up areas with extensive impervious surfaces. Knowledge of the expected change in LST when one land-cover is converted to another can inform land planners of the potential impact of future changes and urges the development of better management strategies

Cancer Biomarker Discovery: The Entropic Hallmark

Background: It is a commonly accepted belief that cancer cells modify their transcriptional state during the progression of the disease. We propose that the progression of cancer cells towards malignant phenotypes can be efficiently tracked using high-throughput technologies that follow the gradual changes observed in the gene expression profiles by employing Shannon's mathematical theory of communication. Methods based on Information Theory can then quantify the divergence of cancer cells' transcriptional profiles from those of normally appearing cells of the originating tissues. The relevance of the proposed methods can be evaluated using microarray datasets available in the public domain but the method is in principle applicable to other high-throughput methods. Methodology/Principal Findings: Using melanoma and prostate cancer datasets we illustrate how it is possible to employ Shannon Entropy and the Jensen-Shannon divergence to trace the transcriptional changes progression of the disease. We establish how the variations of these two measures correlate with established biomarkers of cancer progression. The Information Theory measures allow us to identify novel biomarkers for both progressive and relatively more sudden transcriptional changes leading to malignant phenotypes. At the same time, the methodology was able to validate a large number of genes and processes that seem to be implicated in the progression of melanoma and prostate cancer. Conclusions/Significance: We thus present a quantitative guiding rule, a new unifying hallmark of cancer: the cancer cell's transcriptome changes lead to measurable observed transitions of Normalized Shannon Entropy values (as measured by high-throughput technologies). At the same time, tumor cells increment their divergence from the normal tissue profile increasing their disorder via creation of states that we might not directly measure. This unifying hallmark allows, via the the Jensen-Shannon divergence, to identify the arrow of time of the processes from the gene expression profiles, and helps to map the phenotypical and molecular hallmarks of specific cancer subtypes. The deep mathematical basis of the approach allows us to suggest that this principle is, hopefully, of general applicability for other diseases

Assessment of grassland degradation near Lake Qinghai, West China, using Landsat TM and in situ reflectance spectra data

The severity of grassland degradation near Lake Qinghai, West China was assessed from a Landsat Thematic Mapper (TM) image in conjunction with in situ samples of per cent grass cover and proportion (by weight) of unpalatable grasses (PUG) collected over 1 m(2) sampling plots. Spectral reflectance at each sampling plot was measured with a spectrometer and its location determined with a Global Positioning System (GPS) receiver. After radiometric calibration, the TM image was geometrically rectified. Ten vegetation indices were derived from TM bands 3 and 4, and from the spectral reflectance data at wavelengths corresponding most closely to those of TM3 and TM4. Regression analyses showed that NDVI and SAVI are the most reliable indicators of grass cover and PUG, respectively. Significant relationships between TM bands-derived indices and in situ sampled grass parameters were established only after the former had been calibrated with in situ reflectance spectra data. Through the established regression models the TM image was converted into maps of grass cover parameters. These maps were merged to form a degradation map at an accuracy of 91.7%. It was concluded that TM imagery, in conjunction with in situ grass samples and reflectance spectra data, enabled the efficient and accurate assessment of grassland degradation inside the study area